Health Update: Time Restricted Eating Lowers Fat Gain

RVAchironeuro • March 20, 2023

Hello everyone :

Here is some news about the metabolic mechanisms related to time restricted eating, also called intermittent fasting, can lead to better fat metabolism.

Misalignment of feeding rhythms with the light-dark cycle leads to disrupted peripheral circadian clocks and obesity … Circadian control of adipocyte creatine metabolism underlies the timing of diet-induced thermogenesis, and enhancement of adipocyte circadian rhythms through overexpression of the clock activator brain and muscle Arnt-like protein-1 (BMAL1) ameliorated metabolic complications during diet-induced obesity.  These findings uncover rhythmic creatine-mediated thermogenesis as an essential mechanism that drives metabolic benefits during time-restricted feeding.”

 “Such thermogenesis (fat burning) depended  on the circadian clock of adipocytes  and on increased synthesis of creatine, fueling a futile cycle of ATP turnover in the mitochondria of adipocytes.  These results help to explain the benefits of time-restricted feeding and how circadian disruption can contribute to metabolic disease .”

Bottom Line:

To summarize this paper, eating outside of the natural circadian rhythms leads to weight gain, and eating according to the inborn circadian rhythms by utilizing time-restricted feeding lowers your risk for metabolic disease…such as all cardiovascular diseases, cancer, diabetes, dementia, and all inflammatory based diseases and disorders.

What is the natural circadian rhythm for eating? It appears that the old phrase is right-on: eat breakfast like a king/queen, lunch like a prince/princess and dinner like a pauper…and getting all your calories within a 10-hour window is optimal. Not only that, this type of eating can lower your inflammation even more than just eating an anti-inflammatory food plan by itself.

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Health News Update: Happy New Year 2026! 1.5.26 Hey there everyone: Here is some news you can use to help you age optimally. I have written before about circadian rhythms and meal timing where it has been shown that eTRF (early time restricted feeding) has many benefits. But what happens as we age and shift our mealtimes away from our natural circadian clocks? Here are some snippets from this paper: “Chrononutrition, the study of the timing of eating, has emerged as a modifiable risk factor for adverse health outcomes The role of eating schedules is biologically relevant as dietary intake acts as an environmental cue influencing the circadian clocks of peripheral metabolic tissues and therefore can contribute to circadian misalignment and internal desynchrony 2 , 10 . The emerging evidence largely suggests that later mealtimes, particularly eating during the biological evening, is detrimental to health, Physical and psychological illnesses, including fatigue, oral health problems, depression, anxiety, and multimorbidity, are primarily associated with later breakfast. Later breakfast timing is also associated with increased mortality Importantly, eating breakfast later with aging was linked to a higher risk of death” https://www.nature.com/articles/s43856-025-01035-x meal timing important for health Bottom Line: While this paper focuses on the elderly, it is certainly applicable to all of us. I have seen significant health benefits when people adopt eTRF patters…from better digestion to weight loss, to better sleep, to more energy! Here are two links to my earlier blogs for the info on when to eat for optimal health: https://www.richmondchironeuro.com/health-news-update-when-you-eat-is-critical-to-long-term-health https://www.richmondchironeuro.com/health-news-update-when-we-eat-is-as-critical-as-what-we-eat
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