Health News Update: Why Am I Fixated on an Anti-inflammatory Food Plan?

Mark Smith • February 24, 2025

Hello again everyone:

 

Some of you may know that I am writing a book about how inflammation will cause, perpetuate, and/or aggravate every known human ailment, including aging (also known as ‘inflammaging’). Here is a sentence from my book that explains why I am so focused on the proper type of food plan:

 

“I have not yet seen a satisfactory and stable resolution of a chronic health condition without a clean food plan.”

 

This is why I am always recommending an unprocessed, whole-food, plant-based dietary pattern. Investing your time and effort towards a gradual or comfortable shift to this type of food plan will offer the greatest improvements in health and optimal aging no matter what shape you are in. Refer to my last blog (2.17.25) for help and resources to move into a better approach to food.

 

Additionally, when we live a lifestyle that goes against our inborn circadian clocks, we distort our biology and cause problems with our ability to be healthy and function well. There are two things that really set off our normal/optimal circadian rhythms:

 

When we sleep. To fix this, go to bed before 10 pm and get at least 7.5 hours of sleep. There can be a lot more to this, such as blocking blue light and avoiding screens at night, turning off WiFi at night…however, often fixing when and what we eat makes your sleep way better so start there and see what happens.

 

When we eat. To fix the eat part, I strongly recommend eTRF, or early Time Restricted Feeding. Basically, you consume 80% of your total daily calories by 2 pm, but you always have some type of breakfast before 10 am or within 2 hours of waking. Lunch is your main meal of the day, and you then have a very light dinner, only 20% of your total daily calories, and you consume all of your calories for the entire day within a 10-to-12-hour window. Breakfast like a princess/prince, lunch like a Queen/King, dinner like a pauper…

 

This form of intermittent fasting has many benefits, and one of the greatest ones is that is facilitates autophagy. Autophagy is an essential anti-inflammatory life process that utilizes the immune system to keep your entire body cleaned out of infections, tumors, inflammation, toxins, debris, gunk and more. Autophagy happens primarily at night, during sleep, in the absence of calories. Without autophagy we would die quickly, it is that important.

 

However, effective autophagy needs at least 12 to 14 hours WITHOUT CALORIES OF ANY TYPE. This is why eTRF is so critical to long term health. Imagine that your custodial crew (autophagy) is unable to complete its job, which means that when you wake up in the morning, the place (your body) is only partially cleaned out. You are now living in a hoarder’s house, full of gunk that blocks essential life functions and leads to an accumulation of debris and inflammation. By going to eTRF with an unprocessed, whole-foods plant-based food plan, you can reasonably expect to feel a lot better because you will have lowered your inflammatory burden and realigned your body chemistry via better circadian rhythms.

 

For example, our circadian rhythms cause our body to be insulin sensitive in the morning and have a full digestive crew in the kitchen. By late afternoon, that same meal that we had in the morning will take two to three times as long to process, plus we will be insulin resistant and our blood sugar will stay elevated longer…thus eating heavier dinners can cause indigestion, elevated blood sugar, weight gain, unprocessed foods that alter the microbiome, more inflammation, more cravings, tendency to eat more at night because we cannot feel as full as fast…all because we went against our natural body clocks that say eat less at night and most of your food before 2 pm. We are made that way…why fight it?

 

https://scitechdaily.com/how-intermittent-fasting-extends-life-spans-time-restricted-eating-reshapes-gene-expression-throughout-the-body/

 

Bottom Line:


Combining an unprocessed, whole-food, plant-based food plan with eTRF makes sense if you are looking to avoid or overcome any chronic health issue. This is the foundation your body needs to repair, heal, and revive. It is also a gentle and doable approach that most of us can do without any worries. Give it a try and let me know how it goes, please.

 

(Please note: If you have any diagnosed health condition, clear this with your health care practitioner or do this under some medical supervision. While this approach is extremely safe and most of us can undertake this, it may not be appropriate for some such as those with diabetes.)

 

By Mark Smith August 24, 2026
This is a subtitle for your new post
By Mark Smith August 17, 2026
This is a subtitle for your new post
By Mark Smith August 10, 2026
This is a subtitle for your new post
By Mark Smith August 3, 2026
This is a subtitle for your new post
By Mark Smith July 27, 2026
This is a subtitle for your new post
By Mark Smith July 20, 2026
This is a subtitle for your new post
By Mark Smith July 13, 2026
This is a subtitle for your new post
By Mark Smith July 6, 2026
This is a subtitle for your new post
By Mark Smith June 29, 2026
Health News Update: Pesticides, Cancer & Why Go Organic 6.29.26 Hello everyone: Slowly but surely, despite the health and food industries downplaying the risks, evidence is emerging that the long-term consumption of trace amounts of toxic chemicals can add up to some serious health consequences. “Our process-based model, encompassing 31 key pesticide active ingredients, together with an innovative stratification of cancer cases by developmental lineage, reveals a robust spatial association between environmental pesticide exposure risk and cancer incidence. In pesticide-associated cancer hotspots, exposomic profiling of liver tissue—a primary target of chemical carcinogens—uncovers a distinct transcriptomic signature of pesticide exposure, implicating a non-genotoxic mode of action that disrupts core regulatory circuitries sustaining cell identity. Collectively, these findings strongly support a mechanistic link between pesticide exposure and cancer, challenging assumptions of human non-carcinogenicity derived from reductionist experimental models. This study redefines the exposome as a lineage-conditioned, mechanistically tractable framework and shows how complex pesticide mixtures can contribute to carcinogenic trajectories, with profound and far-reaching implications for global health policy and socio-ecological equity.” https://www.nature.com/articles/s44360-026-00087-0 pesticide exposure & cancer risks Bottom Line: Whenever possible, purchase your food from organic sources including local farmers that use regenerative and organic practices. Not all foods need to be organic, and to decide which ones absolutely need to be, you can access the Environmental Working Group’s yearly list of the Dirty Dozen foods that are the highest in pesticide residues. This will also include the Clean 15 foods that do not need to be organic as they are usually grown without or with very low pesticide levels. https://www.ewg.org/foodnews/dirty-dozen.php dirty dozen food guide Additionally, high quality nutrients support the natural detox processes our bodies use to get rid of any and all toxins. When we consume the Standard American Diet or Westernized Diet, we are low in the nutrients and co-factors needed to support optimal detox cleansing. So always start with food upgrades as they will carry your upgrade the farthest. Remember that most chronic health conditions start 20 years before you even notice them creeping up or becoming diagnosed. What you do now is creating your future. It used to be said that you are what you eat. Another way to say that is we become what we eat…so please take good care and make sure you always put high grade fuel into your Temple.
By Mark Smith June 22, 2026
Health news Update: High Fat Diets Promote Inflammation and Illness 6.22.26 Hello again: This news has been slow to surface with the popularity of keto and paleo dietary trends, but the following information is what is known about the typical Standard American Diet, also known as the Western Diet. “Conclusion : HFD-associated low-grade inflammation results from overlapping effects of dysbiosis and high fat intake, with crosstalk between microbiota and fat-driven inflammatory processes independent of gut flora involving multiple mechanisms. For this reason, it is difficult to determine what occurs first, thus, HFD-driven dysbiosis and HFD-related inflammation should be considered partially independent but closely correlated mechanisms.” https://pmc.ncbi.nlm.nih.gov/articles/PMC8619527/ High fat promotes inflammation Bottom Line: As you all know by now, inflammation will cause, perpetuate, and/or aggravate every known illness or condition, including aging. The next logical question is what to eat? The answer is the Green Mediterranean food plan…which essentially going vegan but allowing some animal-based foods no more than 3 times per week. This takes some planning but is most easily achieved by using a ‘crowding out’ method. This is simply accomplished by including more and more unprocessed, whole plant-based foods in place of processed or fatty foods and naturally reducing those less than healthy items. Below is some more information to help you make the switch…knowing that you can improve your day-to-day nutrition by making small consistent upgraded choices is critical. Upgrades to improve your health path do not usually arise from one big resolution but from those small individual choices made every day…and these add up to some major improvements over several months and longer. “The gut microbiota is responsible for recovering energy from food, providing hosts with vitamins, and providing a barrier function against exogenous pathogens. In addition, it is involved in maintaining the integrity of the intestinal epithelial barrier, crucial for the functional maturation of the gut immune system. The Western diet (WD)—an unhealthy diet with high consumption of fats—can be broadly characterized by overeating, frequent snacking, and a prolonged postprandial state. The term WD is commonly known and intuitively understood. However, the strict digital expression of nutrient ratios is not precisely defined. Based on the US data for 1908–1989, the calory intake available from fats increased from 32% to 45%. Besides the metabolic aspects (hyperinsulinemia, insulin resistance, dyslipidemia, sympathetic nervous system and renin-angiotensin system overstimulation, and oxidative stress), the consequences of excessive fat consumption (high-fat diet—HFD) comprise dysbiosis, gut barrier dysfunction, increased intestinal permeability, and leakage of toxic bacterial metabolites into the circulation. These can strongly contribute to the development of low-grade systemic inflammation.”
More Posts