Preventing Brain Atrophy In Alzheimer’s: It can be done!!

Hello everyone:

This is a pretty astounding paper that reveals how certain B vitamins slowed brain shrinkage and cognitive decline, plus they went even further with great results:

“Is it possible to prevent atrophy of key brain regions related to cognitive decline and Alzheimer’s disease (AD)? One approach is to modify nongenetic risk factors, for instance by lowering elevated plasma homocysteine using B vitamins. In an initial, randomized controlled study on elderly subjects with increased dementia risk (mild cognitive impairment according to 2004 Petersen criteria), we showed that high-dose B-vitamin treatment (folic acid 0.8 mg, vitamin B6 20 mg, vitamin B12 0.5 mg) slowed shrinkage of the whole brain volume over 2 y.”

If that was not enough, look what else they did!!

“Here, we go further by demonstrating that B-vitamin treatment reduces, by as much as seven-fold, the cerebral atrophy in those gray matter (GM) regions specifically vulnerable to the AD process, including the medial temporal lobe.”

Bottom Line: Get your homocysteine lab values checked and if it is high, then lower it using supplemental B vitamins as outlined. You will protect your brain!! Also, in many patients that have ‘brain fog’, lab tests often reveal that they are either deficient or insufficient in those B vitamins, so give them a try. The only warning that is important to know is that the form of the B vitamins is actually very, very important. You definitely want the B vitamins in their ACTIVE form, which means that they are ready to go and do not require processing by the body to activate them. B vitamins in food are NOT activated, but go through a process of activation in our cells. Some estimates are that as many as 1 in 3 of us have defects in these activation processes which leads to our needing much higher dosages to be effective. To overcome this, use the activated forms, which means the label says that B-6 is pyridoxil-5-phosphate, and folic acid is either folinic acid or 5-methy-tetrahydra folate, and B-12 is methylcobalamine or adenosylcobalamine or hydroxocobalamine or some combination of those.

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